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News video games 25 January 2023, 17:50

author: Damian Gacek

How to Create the Best Builds in Bio Prototype

In this guide, we address the issue of builds in Bio Prototype. We will tell you how to create effective combinations so that all enemies fear you.

Bio Prototype is a game that brings to mind Vampire Survivors. This means that we take on the role of a character who runs around the map and fights against successive waves of enemies. We have no direct control over our character's blows, however, we can design the interaction chains between them ourselves so that they are deadly effective. In this article, we will show you how to create the best builds in Bio Prototype.

Remember that the information provided here is based on the early access version of the game, so it may become outdated in the future.

What to keep in mind when creating builds in Bio Prototype

  1. Efficiency – it significantly affects the strength of the organ. However, body parts with the highest factor usually take a long time to recharge. In this case, it is definitely better to rely on speed.
  2. There are 2 types of body parts – circular and diamond-shaped. The former serve as connectors and programme your attacks (it depends on them when you deal a blow). The latter inflict damage and impose damaging effects on enemies.
  3. Culture tab – between waves you can buy upgrades for your character with the points earned during the game, they are also an important part of your build.
  4. Descriptions – organs have their own descriptions, these tell you under what circumstances something will trigger or how much damage it deals, read them.
  5. Test – you can test your builds between games. Unfortunately, the skills that trigger on death have not yet been well pictured in this mode (dummies cannot be killed). So don't worry if not everything works.
  6. Quality – organs have rarity, mostly the higher the better the body part (although ultimately it all depends on whether you have other body parts to put everything together).

What to choose in the Culture tab

  1. Brain - this will allow you to have more connections at once, which is invaluable in the later stages of the game.
  2. Movement speed – in a game about moving and running away from enemies, this is an extremely important statistic.
  3. HP – the more health, the better.
  4. Damage – basic and critical (depending on your organs and how you combine them).
  5. Organ quality – after a while it won't be the quantity of organs that will be an issue, but their quality, always worth upgrading.

How to Create the Best Builds in Bio Prototype

AOE effects

How to Create the Best Builds in Bio Prototype - picture #1

AOE effects are invaluable against hordes of enemies. Combine Poison bag of the Wyvern / Belly of the fire lizard and Intestine of the Monolith with your brain. You will then see circles forming beneath you. Any opponent who enters them will receive damage. If you create the right connection with high-quality components, you will hardly have to move from your position. This is definitely a powerful combination.

Magic missiles

Obviously, the better the Efficiency, the more powerful attacks your character can inflict. However, waiting time is also important. A powerful attack that does not attack quickly enough will lead to your death. It is a good idea to use rapid-fire projectiles and combine other effects with them based on hitting or killing your opponent.

For example, combining an organ that will fire frequently and Belly of the Fire Lizard with Nerve of the Boxer will make your projectiles blazing and deal constant damage to enemies. The downside of this is that Nerve of the Boxer has a low Efficiency, so you cannot count on high damage. It is therefore worth having a quality organ for this.


This mechanic can be very useful when combined with AOE effects. If you can create a combination that allows you to produce these creatures quickly and have the right AOE effects, you will be able to create a fortress. You can read more about it here: Offspring in Bio Prototype Explained; Everything You Need to Know.

Damian Gacek

Damian Gacek

Graduate of English Philology and English in Public Communication. His portfolio includes a scientific article on video game translation. Working with since 2019, writing for various departments. Currently, deals with guides and occasionally supports the newsroom. Interested in electronic entertainment since childhood. Loves RPGs and strategies, often also immersing himself in the depths of indie games. In his free time, works on a book and learns film editing.